Adhesion Receptor Sialoadhesin (Siglec-1) Counterreceptor for the Macrophage Cutting Edge: CD43 Functions as a T Cell
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منابع مشابه
Sialylation of the sialic acid binding lectin sialoadhesin regulates its ability to mediate cell adhesion.
The macrophage-specific cell surface receptor sialoadhesin, which is a member of the newly recognized family of sialic acid binding lectins called siglecs, binds glycoprotein and glycolipid ligands containing a2-3-linked sialic acid on the surface of several leukocyte subsets. Recently, the sialic acid binding activity of the siglec CD22 has been demonstrated to be regulated by sialylation of t...
متن کاملMolecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)
In recent years, several entry mediators have been characterized for porcine reproductive and respiratory syndrome virus (PRRSV). Porcine sialoadhesin [pSn, also known as sialic acid-binding immunoglobulin-type lectin (Siglec-1)] and porcine CD163 (pCD163) have been identified as the most important host entry mediators that can fully coordinate PRRSV infection into macrophages. However, recent ...
متن کاملCharacterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
Sialoadhesin is a macrophage-restricted cellular interaction molecule and a prototypic member of the Siglec family of sialic acid binding immunoglobulin (Ig)-like lectins. So far, it has only been characterized in rodents. Here, we report the molecular cloning, binding properties, and expression pattern of human sialoadhesin. The predicted protein sequences of human and mouse sialoadhesin are a...
متن کاملSiglecs in the immune system.
Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins characterized by an N-terminal V-set Ig domain that mediates sialic acid binding, followed by varying numbers of C2-set Ig domains (Fig. 1). The initial discovery of this lectin family came about through independent studies on sialoadhesin (Siglec-1/CD169), a macrophage lectin-like adhesion molecule, and CD22 (Siglec-2),...
متن کاملSialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule
In this study we present evidence that the mouse and rat sialoadhesin (originally named sheep erythrocyte receptor) on macrophages can function as a lymphocyte adhesion molecule. Lymphocytes were shown to bind to the splenic marginal zone, and lymph node subcapsular sinus and medulla in a frozen section assay. Selective depletion experiments showed that binding was mediated by macrophages. Adhe...
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